How Do Cannabinoids Work with the Body?

Cannabinoids are chemical compounds in the hemp plant that interact with the body’s endocannabinoid system (ECS). The ECS is responsible for maintaining homeostasis within the body, and the cannabinoids work as part of this system to help achieve balance.

This article will explore how cannabinoids interact with the body’s ECS and their potential benefits.

READ: Who Discovered The Cannabinoid Receptors For CBD And THC? How Do They Affect Your Body?

What Are Cannabinoids?

thc-h cannabinoids

Cannabinoids are compounds in the hemp plant, such as CBD, that interact with the body’s Endocannabinoid System (ECS). This system, discovered in the 1990s, is believed to be responsible for maintaining homeostasis within the body. It comprises endogenous cannabinoids, receptors, and enzymes that break down the cannabinoids once they have done their job.

Endogenous Cannabinoids

Endogenous cannabinoids, also known as endocannabinoids, are compounds made by the body that interact with the receptors of the ECS. They regulate various functions such as appetite, sleep, pain, and mood. Anandamide and 2-arachidonoylglyerol (2-AG) are the most widely studied endocannabinoid.

What Is The Endocannabinoid System?

The endocannabinoid system (ECS) is a complex network of receptors, enzymes, and endogenous cannabinoids throughout the body. Its primary role is maintaining homeostasis, or balance, within the body.

The ECS comprises three main components: endocannabinoids (cannabinoids made by the body), receptors (to receive endocannabinoids), and enzymes that break down the endocannabinoids once they have done their job.

How Do Cannabinoids Work With The Endocannabinoid System?

cannabinoid receptors

Plant-made cannabinoids, such as those found in the hemp plant, interact with the body’s endocannabinoids similarly. These compounds fit the receptors and help support the body’s various functions. This interaction can potentially lead to a variety of beneficial effects, both in the short-term and long-term.

READ: What Are The Big Six Cannabinoids?


The ECS has two types of receptors: CB1 and CB2. CB1 receptors are located mainly in the brain and central nervous system, while CB2 receptors are primarily in the peripheral nervous system. The receptors respond to endocannabinoids and cannabinoids found in the hemp plant. When activated, they help regulate various physiological processes.


The enzymes of the ECS are responsible for breaking down endocannabinoids and cannabinoids once they have done their job. Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) are two of the major enzymes involved in the breakdown of endocannabinoids.

Plant-Made Cannabinoids

Plant-made cannabinoids, such as those found in the hemp plant, interact with the body’s endocannabinoids. They bind to the receptors of the ECS and help regulate various physiological processes. CBD is one of the most well-studied cannabinoids and is believed to have multiple therapeutic benefits.

The Entourage Effect

The Entourage Effect is an essential concept in Cannabis and Cannabinoid Therapy. It refers to how all cannabinoids, terpenes, and flavonoids in a single plant interact to create a synergistic effect that produces more significant therapeutic benefits than any individual element of the plant would offer separately. The Entourage Effect emphasizes how the entire plant matrix works as a single unit to create unique synergistic relationships, maximizing the potential health benefits of each Cannabinoid.

This range of interactions leads to a greater diversity of possible outcomes that may be unique to each user. As research in this area continues, we have begun to understand that this effect is significant in understanding the potential therapeutic benefits of cannabis and utilizing its truly incredible potential.

The Potential Benefits Of Cannabinoids


The potential benefits of cannabinoids are many. Studies have found that cannabinoids may help reduce inflammation, improve mood, reduce anxiety, improve sleep, and even help with chronic pain. Additionally, cannabinoids may be beneficial in treating various conditions, such as epilepsy, multiple sclerosis, Crohn’s disease, and irritable bowel syndrome.

Best Place To Find Cannabinoid Products?

Five CBD is the premier destination for all your real cannabinoid needs. They are committed to making high-quality, scientifically-backed products that deliver only pure cannabinoids with no added fillers or chemicals. Every product is made with the highest standards of ethics, sustainability, and safety in mind. They have an extensive selection of hemp-derived CBD products, which include gummies, oils, tinctures, vapes, topical salves, and edibles.

And if that wasn't enough, they also offer CBG, CBN, and other minor cannabinoids to ensure a well-rounded cannabinoid experience. In addition, they go the extra mile to understand the science behind cannabinoids, providing users with educational resources and guidance to help inform decisions on dosing, product selection, possible interactions, and other matters of hemp-derived CBD. All of this adds up to Five CBD being the perfect choice for cannabinoid products. Use Coupon Code 25FIVE for 25% off your next order.

READ: Is CBD Stronger Than Hemp?

How Do Cannabinoids Work with the Body? - Conclusion

Cannabinoids, made by the body and those found in the hemp plant, interact with the body’s Endocannabinoid System. Endogenous cannabinoids, receptors, and enzymes are all involved in this process, which helps regulate various physiological processes. Plant-made cannabinoids, such as CBD, have been found to have a variety of therapeutic benefits.